Bioinformatics Resources and Tools for Conformational B-Cell Epitope Prediction. (21st July 2013)

• Record Type: Journal Article
• Authors: Sun, Pingping; Ju, Haixu; Liu, Zhenbang; Ning, Qiao; Zhang, Jian; Zhao, Xiaowei; Huang, Yanxin; Ma, Zhiqiang; Li, Yuxin
• Other Names: Huang Jian Academic Editor.
• Is Part Of: Computational and mathematical methods in medicine. Volume 2013(2013)
• Publication Date: 2013-07-21
• Subjects: Medicine -- Computer simulation -- Periodicals; Medicine -- Mathematical models -- Periodicals; 610.11
• DOI: 10.1155/2013/943636
• Languages: English
• ISSNs: 1748-670X

Abstract

Abstract : Identification of epitopes which invoke strong humoral responses is an essential issue in the field of immunology. Localizing epitopes by experimental methods is expensive in terms of time, cost, and effort; therefore, computational methods feature for its low cost and high speed was employed to predict B-cell epitopes. In this paper, we review the recent advance of bioinformatics resources and tools in conformational B-cell epitope prediction, including databases, algorithms, web servers, and their applications in solving problems in related areas. To stimulate the development of better tools, some promising directions are also extensively discussed.