Abnormal resting-state functional connectivity in patients with obsessive-compulsive disorder: A systematic review and meta-analysis. (April 2022)

• Record Type: Journal Article
• Authors: Liu, Jing; Cao, Lingxiao; Li, Hailong; Gao, Yingxue; Bu, Xuan; Liang, Kaili; Bao, Weijie; Zhang, Suming; Qiu, Hui; Li, Xue; Hu, Xinyue; Lu, Lu; Zhang, Lianqing; Hu, Xinyu; Huang, Xiaoqi; Gong, Qiyong
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 135(2022)
• Publication Date: 2022-04
• Subjects: Obsessive-compulsive disorder -- Resting-state fMRI -- Seed-based functional connectivity -- Circuit -- Meta-analysis -- Systematic review; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2022.104574
• Languages: English
• ISSNs: 0149-7634

Abstract

Abstract: Obsessive-compulsive disorder (OCD) displays widespread disruption across brain regions revealed by resting-state functional connectivity (rsFC) with inconsistent results between studies. We performed a systematic review of 47 seed-based rsFC studies (1863 patients; 1795 healthy controls) to explore brain intrinsic connectivity alterations. Quantitative coordinate-based meta-analysis was conducted for seed regions in the striatum (putamen, caudate, nucleus accumbens [Nac]), thalamus, and anterior cingulate cortex (ACC) because there were an adequate number of studies. We found that OCD patients demonstrated (1) characteristic dysconnectivity between striatum and cortical networks (i.e., caudate hyperconnectivity with the fronto-limbic network and hypoconnectivity with frontoparietal network regions; Nac hypoconnectivity with fronto-limbic network regions), (2) hypoconnectivity between thalamus and striatum (putamen and caudate), and (3) dysconnectivity between the ACC and fronto-limbic network regions. Furthermore, there were negative correlations between particular connectivities and symptom severity and onset age. Our results characterize the traditional cortico-striato-thalamo-cortical circuit model of OCD pathophysiology through the cerebral intrinsic connectivity, and unified neurocircuitry and brain network models into one integrity to elaborate the neural mechanism of OCD. Highlights: This study is a systematic review of seed-based resting-state functional connectivity studies in OCD. Striatum, thalamus, and anterior cingulate cortex (ACC) are the most commonly used seeds in original studies. We demonstrated specific functional connectivity alterations within distinct striatal circuits. The ACC showed abnormal connectivity with the prefrontal cortex. There were negative correlations between certain connectivity and symptom severity and age of onset.