A stable start: cotranslational Nt-acetylation promotes proteome stability across kingdoms. Issue 5 (May 2022)

• Record Type: Journal Article
• Authors: Gibbs, Daniel J.; Bailey, Mark; Etherington, Ross D.
• Is Part Of: Trends in cell biology. Volume 32:Issue 5(2022)
• Page Start: 374
• Page End: 376
• Publication Date: 2022-05
• Subjects: acetylation -- N terminus -- cotranslational modification -- proteolysis -- N-degron pathway -- proteostasis; Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2022.02.004
• Languages: English
• ISSNs: 0962-8924

Abstract

Abstract : Two recent studies show that cotranslational N-terminal protein acetylation (NTA) promotes proteome stability in humans (Mueller et al . ) and plants (Linster et al . ) by masking nonacetylated N-degrons that would otherwise destabilise proteins. This is in contrast to previous findings linking NTA to degradation, suggesting that this widespread mark has complex and context-specific functions in regulating protein half-lives.