Multifunctional effects of wound dressing based on chitosan-coordinated argentum with resistant bacterial penetration. (15th July 2022)

• Record Type: Journal Article
• Authors: Wang, Yanting; Ma, Yanhui; Jiang, Zhiwen; Hu, Huiwen; Wang, Shuo; Chi, Jinhua; Qiao, Jing; Zhang, Wei; Wang, Zheng; Liu, Wanshun; Han, Baoqin
• Is Part Of: Carbohydrate polymers. Volume 288(2022)
• Publication Date: 2022-07-15
• Subjects: Antibacterial activities -- Biosafety -- Carboxymethyl chitosan -- Wound healing; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.119329
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Third-degree scald, causing serious tissue destruction with continuous pain, easily leads to microbial infections and delayed wound healing. Therefore, a multifunctional treatment is attractive for seriously damaged tissue. Herein, carboxymethyl chitosan-coordinated argentum (Ag-CMC) was synthesized via a complexation method, and then the Ag + release, antibacterial activity, biocompatibility, pain relief and wound healing properties of Ag-CMC were investigated in vitro and in vivo . The results revealed that Ag + had interacted with carboxymethyl chitosan, containing approximately 1.2% of silver. The Ag-CMC (50–200 μg/mL) with Ag + sustained release exhibited significant antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, drug-resistant E. coli, PA, MRSA and good biocompatibility with L929 cells. Furthermore, antibacterial and wound healing experiments demonstrated that Ag-CMC achieved an effective contraction rate of 90% after 28 days by accelerating re-epithelialization, regulating inflammation response, relieving pain and infections. Therefore, Ag-CMC is a safe multifunctional treatment for wound healing and infections. Graphical abstract: Unlabelled Image