Transdermal oxycodone patch for the treatment of postherpetic neuralgia: a randomized, double-blind, controlled trial. (July 2017)

• Record Type: Journal Article
• Authors: Gavin, Paul D; Tremper, Louise; Smith, Alisha; Williams, Gemma; Brooker, Charles
• Is Part Of: Pain management. Volume 7:Number 4(2017)
• Page Start: 255
• Page End: 267
• Publication Date: 2017-07
• Subjects: oxycodone -- postherpetic neuralgia -- transdermal patch; Pain -- Treatment -- Periodicals; 616.047205
• DOI: 10.2217/pmt-2016-0067
• Languages: English
• ISSNs: 1758-1869

Abstract

Aim: To evaluate the efficacy, systemic exposure, safety and tolerability of a transdermal oxycodone patch containing tocopheryl phosphate mixture (TPM) in patients with postherpetic neuralgia (PHN).Patients & methods: The study was a Phase IIa, multicenter, randomized, double-blind, vehicle-controlled crossover study.Results: While the TPM/oxycodone patch did not significantly improve 'average' Numeric Pain Rating Scale scores versus vehicle patch, patients reporting high levels of paresthesia (n = 9) showed a trend toward improved pain reduction. The TPM/oxycodone patch resulted in a low systemic exposure to oxycodone and was well tolerated.Conclusion: The TPM/oxycodone patch delivered oxycodone to the site of perceived pain in subjects suffering from PHN, but did not provide analgesia for the broad PHN indication.