Pharmacogenetic analysis of hepatitis C virus related mixed cryoglobulinemia. (May 2017)

• Record Type: Journal Article
• Authors: Cusato, Jessica; Boglione, Lucio; De Nicolò, Amedeo; Cardellino, Chiara Simona; Carcieri, Chiara; Cariti, Giuseppe; Di Perri, Giovanni; D'Avolio, Antonio
• Is Part Of: Pharmacogenomics. Volume 18:Number 7(2017)
• Page Start: 607
• Page End: 611
• Publication Date: 2017-05
• Subjects: ABCB1 -- cryoglobulin -- HCV -- HCV extra hepatic manifestation -- NT5 -- pegylated interferon/ribavirin -- pharmacogenetics -- SNPs; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs-2016-0040
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: Mixed cryoglobulinemia (MC) is an extra hepatic hepatitis C virus related problem and different studies suggested genetics' role in predicting this complication. We evaluated the influence of SNPs in IL-28B, SLC29A1, SLC28A2, NT5C2, HNF4 and ABCB1 genes in MC prediction.Patients & methods: SNPs were evaluated through real-time PCR.Results: ABCB1 (gene encoding P-glycoprotein) 3435C>T SNP was associated with MC presence (p = 0.034): related to T allele carriers (CC vs CT/TT), we reached a p-value of 0.013. In the logistic regression analysis baseline viral load >600.000 IU/ml (p < 001), IL28B rs8099917/rs12979860 TT/CC (p < 0.001), NT5 (gene encoding for 5′ nucleotidase) 153 TC (p = 0.012) and ABCB1 3435 CT/TT (p = 0.034) genotypes predicted MC presence.Conclusion: These data could help clinicians to identify patients with higher probability to show MC extra hepatic complication.