The Dynamic Optical Breast Imaging in the Preoperative Workflow of Women with Suspicious or Malignant Breast Lesions: Development of a New Comprehensive Score. (27th September 2012)

• Record Type: Journal Article
• Authors: D'Aiuto, Massimiliano; Frasci, Giuseppe; Barretta, Maria Luisa; Gallipoli, Adolfo; Ciuffo, Giovanni Maria; Musco, Flavia; Orefice, Sergio; Frattini, Viviana; Guidi, Ilves; Siani, Claudio; Esposito, Emanuela; Crispo, Anna; Montella, Maurizio; Chirico, Andrea; D'Aiuto, Giuseppe; Vecchione, Aldo
• Other Names: Loizidou M. Academic Editor.; Yu Y. Academic Editor.
• Is Part Of: ISRN oncology. Volume 2012(2012)
• Publication Date: 2012-09-27
• Subjects: Oncology -- Periodicals; Neoplasms; Oncology; Periodicals; 616.994
• DOI: 10.5402/2012/631917
• Languages: English
• ISSNs: 2090-5661

Abstract

Abstract : Purpose . To determine the diagnostic accuracy of DOBIComfortScan in patients with Breast Imaging Reporting suspect breast lesions (BI-RADS) 4-5 breast lesions. Materials and Methods . One-hundred and thirteen patients underwent DOBIComfortScan examination before surgery. Twelve parameters were taken into consideration to define DOBI findings. Results . Twenty-seven radical mastectomies, 47 quadrantectomies and 39 wide excisions, were performed. Overall, 65 invasive cancer, 9 in situ carcinoma and 39 nonmalignant lesions, were observed. Ten out of 12 considered parameters resulted significantly in association with histology at discriminant analysis. A summation score of 30.5 resulted to be the best cut off at ROC analysis, giving a sensitivity and specificity of 80% and 87%, respectively, and a positive predictive value of 92.2%. Finally the following DOBI-BI-RADS model was developed: malignant B 5 ≥ 38 score); possibly malignant (B 4 = 25 - 37 score); benign but the possibility of malignancy cannot be excluded (B 3 = 20 - 24 score); benign (B 2 < 20 score). Conclusion . definition of other parameters permits to improve the accuracy of this procedure. Further studies are warranted to define the potential role of DOBIComfortScan in breast cancer imaging.