General Aspects of Colorectal Cancer. (14th November 2012)

• Record Type: Journal Article
• Authors: Centelles, Josep J.
• Other Names: Al-Ali H. Academic Editor.; Fujimoto N. Academic Editor.; Mutti L. Academic Editor.; Nahta R. Academic Editor.
• Is Part Of: ISRN oncology. Volume 2012(2012)
• Publication Date: 2012-11-14
• Subjects: Oncology -- Periodicals; Neoplasms; Oncology; Periodicals; 616.994
• DOI: 10.5402/2012/139268
• Languages: English
• ISSNs: 2090-5661

Abstract

Abstract : Colorectal cancer (CRC) is one of the main causes of death. Cancer is initiated by several DNA damages, affecting proto-oncogenes, tumour suppressor genes, and DNA repairing genes. The molecular origins of CRC are chromosome instability (CIN), microsatellite instability (MSI), and CpG island methylator phenotype (CIMP). A brief description of types of CRC cancer is presented, including sporadic CRC, hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndromes, familiar adenomatous polyposis (FAP), MYH-associated polyposis (MAP), Peutz-Jeghers syndrome (PJS), and juvenile polyposis syndrome (JPS). Some signalling systems for CRC are also described, including Wnt- β -catenin pathway, tyrosine kinase receptors pathway, TGF- β pathway, and Hedgehog pathway. Finally, this paper describes also some CRC treatments.