Intracellular delivery of proteins by nanocarriers. (April 2017)

• Record Type: Journal Article
• Authors: Ray, Moumita; Lee, Yi-Wei; Scaletti, Federica; Yu, Ruijin; Rotello, Vincent M
• Is Part Of: Nanomedicine. Volume 12:Number 8(2017)
• Page Start: 941
• Page End: 952
• Publication Date: 2017-04
• Subjects: cytosolic delivery -- nanoparticle-stabilized nanocapsules -- nuclear targeting -- protein -- punctate fluorescence; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2016-0393
• Languages: English
• ISSNs: 1743-5889

Abstract

Intracellular delivery of proteins is potentially a game-changing approach for therapeutics. However, for most applications, the protein needs to access the cytosol to be effective. A wide variety of strategies have been developed for protein delivery, however access of delivered protein to the cytosol without acute cytotoxicity remains a critical issue. In this review we discuss recent trends in protein delivery using nanocarriers, focusing on the ability of these strategies to deliver protein into the cytosol.