Development of genipin-crosslinked fucoidan/chitosan-N-arginine nanogels for preventing Helicobacter infection. (June 2017)

• Record Type: Journal Article
• Authors: Lin, Yu-Hsin; Lu, Kun-Ying; Tseng, Ching-Li; Wu, Jui-Yu; Chen, Chien-Ho; Mi, Fwu-Long
• Is Part Of: Nanomedicine. Volume 12:Number 12(2017)
• Page Start: 1491
• Page End: 1510
• Publication Date: 2017-06
• Subjects: antibacterial -- chitosan -- drug delivery -- fucoidan -- H. pylori -- nanogels -- nanoparticles; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2017-0055
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: This study aims to validate the anti- Helicobacter pylori efficacy of amoxicillin-loaded nanoparticles and nanogels with pH-responsive and site-specific drug release properties against H. pylori infection.Materials & methods: Genipin-crosslinked low molecular weight fucoidan/chitosan- N -arginine nanogels (FCSA) were prepared for targeted delivery of amoxicillin to the site of H. pylori infected AGS gastric epithelial cells.Results: The negatively charged nanogels (n-FCSA) adhered to H. pylori and exhibited pH-responsive drug release property to reduce cytotoxic effects in H. pylori infected AGS cells.Conclusion: These in vitro findings suggest that n-FCSA nanogels are potential carriers for H. pylori specific delivery of antibacterial agents, and provide the basis for further studies on the clinical use of the nanogels.