Nanoemulsion is an effective antimicrobial for methicillin-resistant Staphylococcus aureus in infected wounds. (May 2017)

• Record Type: Journal Article
• Authors: Cao, Zhengyi; Spilker, Theodore; Fan, Yongyi; Kalikin, Linda M; Ciotti, Susan; LiPuma, John J; Makidon, Paul E; Wilkinson, John Erby; Baker, James R; Wang, Su He
• Is Part Of: Nanomedicine. Volume 12:Number 10(2017)
• Page Start: 1177
• Page End: 1185
• Publication Date: 2017-05
• Subjects: antimicrobial -- infected wounds -- methicillin-resistant Staphylococcus aureus -- nanoemulsion -- NB-201; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2017-0025
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: To develop NB-201, a nanoemulsion compound, as a novel microbicidal agent against methicillin-resistant Staphylococcus aureus (MRSA) infection, which is a common threat to public health but with limited therapeutic options.Materials & methods: NB-201 was tested in in vitro and in vivo murine and porcine models infected with MRSA.Results: Topical treatment of MRSA-infected wounds with NB-201 significantly decreased bacterial load and had no toxic effects on healthy skin tissues. NB-201 attenuated neutrophil sequestration in MRSA-infected wounds and inhibited epidermal and deep dermal inflammation. The levels of proinflammatory cytokines were reduced in NB-201-treated MRSA-infected wounds.Conclusion: NB-201 can greatly reduce inflammation characteristic of infected wounds and has antimicrobial activity that effectively kills MRSA regardless of the genetic basis of antibiotic resistance.