Cannabidiol in the management of in-patient cannabis withdrawal: clinical case series. (August 2017)

• Record Type: Journal Article
• Authors: Pokorski, Izabella; Clement, Nicole; Phung, Nghi; Weltman, Marin; Fu, Shanlin; Copeland, Jan
• Is Part Of: Future neurology. Volume 12:Number 3(2017)
• Page Start: 133
• Page End: 140
• Publication Date: 2017-08
• Subjects: abstinence -- cannabinoid -- cannabis -- detoxification -- marijuana -- treatment; Neurology -- Research -- Periodicals; 611.8005
• DOI: 10.2217/fnl-2016-0035
• Languages: English
• ISSNs: 1479-6708

Abstract

Aim: To assess the feasibility of the use of cannabidiol (CBD) for the management of cannabis withdrawal.Patients & methods: Eight participants were admitted to an in-patient detoxification facility for a 7-day open-label trial of CBD. Five participants received 600 mg of CBD and three participants received 1200 mg of CBD. Participants returned for a 28-day follow-up interview.Results & conclusion: CBD was well tolerated by all participants. Five completed the full treatment period and abstinence was maintained by four participants at day 28 follow-up. All those receiving the higher dose completed treatment and achieved abstinence at follow-up. This pilot study suggests that further exploration of CBD as a pharmacological adjunctive therapy for cannabis withdrawal and dependence is warranted. Registration ACTRN1261400024866.