Clinical, Functional, and Mental Health Outcomes in Kidney Transplant Recipients 3 Months After a Diagnosis of COVID-19. Issue 5 (26th April 2022)

• Record Type: Journal Article
• Authors: Duivenvoorden, Raphaël; Vart, Priya; Noordzij, Marlies; Soares dos Santos, Augusto C.; Zulkarnaev, Alex B.; Franssen, Casper F. M.; Kuypers, Dirk; Demir, Erol; Rahimzadeh, Hormat; Kerschbaum, Julia; Jager, Kitty J.; Turkmen, Kultigin; Hemmelder, Marc H.; Schouten, Marcel; Rodríguez-Ferrero, María Luisa; Crespo, Marta; Gansevoort, Ron T.; Hilbrands, Luuk B.
• Other Names: van der Net Jeroen B. author non-byline.; Essig Marie author non-byline.; du Buf-Vereijken Peggy W.G. author non-byline.; van Ginneken Betty author non-byline.; Maas Nanda author non-byline.; Vogt Liffert author non-byline.; van Jaarsveld Brigit C. author non-byline.; Bemelman Frederike J. author non-byline.; Klingenberg-Salahova Farah author non-byline.; Heenan-Vos Frederiek author non-byline.; Vervloet Marc G. author non-byline.; Nurmohamed Azam author non-byline.; Abramowicz Daniel author non-byline.; Verhofstede Sabine author non-byline.; Maoujoud Omar author non-byline.; Malfait Thomas author non-byline.; Fialova Jana author non-byline.; Melilli Edoardo author non-byline.; Favà Alexandre author non-byline.; Cruzado Josep M. author non-byline.; Montero Perez Nuria author non-byline.; Lips Joy author non-byline.; Krepel Harmen author non-byline.; Adilovic Harun author non-byline.; Hengst Maaike author non-byline.; Konings Constantijn author non-byline.; Rydzewski Andrzej author non-byline.; Braconnier Philippe author non-byline.; Weis Daniel author non-byline.; Gellert Ryszard author non-byline.; Oliveira João author non-byline.; Alferes Daniela G. author non-byline.; Radulescu Daniela author non-byline.; Zakharova Elena V. author non-byline.; Ambuehl Patrice Max author non-byline.; Guidotti Rebecca author non-byline.; Walker Andrea author non-byline.; Lepeytre Fanny author non-byline.; Rabaté Clémentine author non-byline.; Rostoker Guy author non-byline.; Marques Sofia author non-byline.; Azasevac Tijana author non-byline.; Strazmester Majstorovic Gordana author non-byline.; Katicic Dajana author non-byline.; ten Dam Marc author non-byline.; Krüger Thilo author non-byline.; Brzosko Szymon author non-byline.; Liakopoulos Vassilios author non-byline.; Zanen Adriaan L. author non-byline.; Logtenberg Susan J.J. author non-byline.; Fricke Lutz author non-byline.; Kuryata Olexandr author non-byline.; Slebe Jeroen J.P. author non-byline.; Abd ElHafeez Samar author non-byline.; Kemlin Delphine author non-byline.; van de Wetering Jacqueline author non-byline.; Reinders Marlies E.J. author non-byline.; Hesselink Dennis A. author non-byline.; Kal-van Gestel J. author non-byline.; Eiselt Jaromir author non-byline.; Kielberger Lukas author non-byline.; El-Wakil Hala S. author non-byline.; Verhoeven Martine author non-byline.; Logan Ian author non-byline.; Canal Cristina author non-byline.; Facundo Carme author non-byline.; Ramos Ana M. author non-byline.; Debska-Slizien Alicja author non-byline.; Veldhuizen Nicoline M.H. author non-byline.; Tigka Eirini author non-byline.; Polyzou Konsta Maria Anna author non-byline.; Panagoutsos Stylianos author non-byline.; Mallamaci Francesca author non-byline.; Postorino Adele author non-byline.; Cambareri Francesco author non-byline.; Matceac Irina author non-byline.; Nistor Ionut author non-byline.; Covic Adrian author non-byline.; Groeneveld J.H.M. author non-byline.; Jousma Jolanda author non-byline.; van Buren Marjolijn author non-byline.; Diekmann Fritz author non-byline.; Oppenheimer Federico author non-byline.; Blasco Miquel author non-byline.; Assis Pereira Tiago author non-byline.; Arias-Cabrales Carlos author non-byline.; Llinàs-Mallol Laura author non-byline.; Buxeda Anna author non-byline.; Tàrrega Carla Burballa author non-byline.; Redondo-Pachon Dolores author non-byline.; Jimenez Maria Dolores Arenas author non-byline.; Mendoza-Valderrey Alberto author non-byline.; Martins Ana Cristina author non-byline.; Mateus Catarina author non-byline.; Alvila Goncalo author non-byline.; Laranjinha Ivo author non-byline.; Hofstra Julia M. author non-byline.; Siezenga Machiel A. author non-byline.; Franco Antonio author non-byline.; Arroyo David author non-byline.; Castellano Sandra author non-byline.; Balda Manzanos Sagrario author non-byline.; Sosa Barrios R. Haridian author non-byline.; Lemahieu Wim author non-byline.; Bartelet Karlijn author non-byline.; Burak Dirim Ahmet author non-byline.; Sukru Sever Mehmet author non-byline.; Turkmen Aydin author non-byline.; Şafak Seda author non-byline.; Hollander Daan A.M.J. author non-byline.; Büttner Stefan author non-byline.; de Vries Aiko P.J. author non-byline.; Meziyerh Soufian author non-byline.; van der Helm Danny author non-byline.; Mallat Marko author non-byline.; Bouwsma Hanneke author non-byline.; Sridharan Sivakumar author non-byline.; Petruliene Kristina author non-byline.; Maloney Sharon-Rose author non-byline.; Verberk Iris author non-byline.; van der Sande Frank M. author non-byline.; Christiaans Maarten H.L. author non-byline.; Mohan Kumar N author non-byline.; Di Luca Marina author non-byline.; Tuğlular Serhan Z. author non-byline.; Kramer Andrea author non-byline.; Beerenhout Charles author non-byline.; Luik Peter T. author non-byline.; Tiefenthaler Martin author non-byline.; Watschinger Bruno author non-byline.; Adema Aaltje Y. author non-byline.; Stepanov Vadim A. author non-byline.; Gandolfini Ilaria author non-byline.; Maggiore Umberto author non-byline.; Fliedner Anselm author non-byline.; Åsberg Anders author non-byline.; Mjoen Geir author non-byline.; Miyasato Hitoshi author non-byline.; de Fijter Carola W.H. author non-byline.; Mongera Nicola author non-byline.; Pini Stefano author non-byline.; de Biase Consuelo author non-byline.; Kerckhoffs Angele author non-byline.; van de Logt Anne Els author non-byline.; Maas Rutger author non-byline.; Lebedeva Olga author non-byline.; Lopez Veronica author non-byline.; Reichert Louis J.M. author non-byline.; Verhave Jacobien author non-byline.; Titov Denis author non-byline.; Parshina Ekaterina V. author non-byline.; Zanoli Luca author non-byline.; Marcantoni Carmelita author non-byline.; van Kempen Gijs author non-byline.; van Gils-Verrij Liesbeth E.A. author non-byline.; Harty John C. author non-byline.; Meurs Marleen author non-byline.; Myslak Marek author non-byline.; Battaglia Yuri author non-byline.; Lentini Paolo author non-byline.; den Deurwaarder Edwin author non-byline.; Stendahl Maria author non-byline.; Rychlik Ivan author non-byline.; Cabezas-Reina Carlos J. author non-byline.; Maria Roca Ana author non-byline.; Nauta Ferdau author non-byline.; Sahin İdris author non-byline.; Goffin Eric author non-byline.; Kanaan Nada author non-byline.; Labriola Laura author non-byline.; Devresse Arnaud author non-byline.; Diaz-Mareque Anabel author non-byline.; Coca Armando author non-byline.; de Arriba Gabriel author non-byline.; Meijers Björn K.I. author non-byline.; Naesens Maarten author non-byline.; Desschans Bruno author non-byline.; Tonnerlier Annelies author non-byline.; Wissing Karl M. author non-byline.; Dedinska Ivana author non-byline.; Pessolano Giuseppina author non-byline.; Malik Shafi author non-byline.; Dounousi Evangelia author non-byline.; Papachristou Evangelos author non-byline.; Berger Stefan P. author non-byline.; Meijer Esther author non-byline.; Sanders Jan Stephan F. author non-byline.; Özyilmaz Akin author non-byline.; Buturović Ponikvar Jadranka author non-byline.; Marn Pernat Andreja author non-byline.; Kovac Damjan author non-byline.; Arnol Miha author non-byline.; Ekart Robert author non-byline.; Abrahams Alferso C. author non-byline.; Molenaar Femke M. author non-byline.; van Zuilen Arjan D. author non-byline.; Meijvis Sabine C.A. author non-byline.; Dolmans Helma author non-byline.; Tantisattamo Ekamol author non-byline.; Esposito Pasquale author non-byline.; Krzesinski Jean-Marie author non-byline.; Barahira Jean Damacène author non-byline.; Gallieni Maurizio author non-byline.; Martin-Moreno Paloma Leticia author non-byline.; Guglielmetti Gabriele author non-byline.; Guzzo Gabriella author non-byline.; Toapanta Nestor author non-byline.; Jose Soler Maria author non-byline.; Luik Antinus J. author non-byline.; van Kuijk Willi H.M. author non-byline.; Stikkelbroeck Lonneke W.H. author non-byline.; Hermans Marc M.H. author non-byline.; Rimsevicius Laurynas author non-byline.; Righetti Marco author non-byline.; Islam Mahmud author non-byline.; Heitink-ter Braak Nicole author non-byline.;
• Is Part Of: Transplantation. Volume 106:Issue 5(2022)
• Page Start: 1012
• Page End: 1023
• Publication Date: 2022-04-26
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; Transplantation immunology -- Periodicals; 617.95
• DOI: 10.1097/TP.0000000000004075
• Languages: English
• ISSNs: 0041-1337

Abstract

Abstract : Background: Kidney transplant patients are at high risk for coronavirus disease 2019 (COVID-19)–related mortality. However, limited data are available on longer-term clinical, functional, and mental health outcomes in patients who survive COVID-19. Methods: We analyzed data from adult kidney transplant patients in the European Renal Association COVID-19 Database who presented with COVID-19 between February 1, 2020, and January 31, 2021. Results: We included 912 patients with a mean age of 56.7 (±13.7) y. 26.4% were not hospitalized, 57.5% were hospitalized without need for intensive care unit (ICU) admission, and 16.1% were hospitalized and admitted to the ICU. At 3 mo follow-up survival was 82.3% overall, and 98.8%, 84.2%, and 49.0%, respectively, in each group. At 3 mo follow-up biopsy-proven acute rejection, need for renal replacement therapy, and graft failure occurred in the overall group in 0.8%, 2.6%, and 1.8% respectively, and in 2.1%, 10.6%, and 10.6% of ICU-admitted patients, respectively. Of the surviving patients, 83.3% and 94.4% reached their pre–COVID-19 physician-reported functional and mental health status, respectively, within 3 mo. Of patients who had not yet reached their prior functional and mental health status, their treating physicians expected that 79.6% and 80.0%, respectively, still would do so within the coming year. ICU admission was independently associated with a low likelihood to reach prior functional and mental health status. Conclusions: In kidney transplant recipients alive at 3-mo follow-up, clinical, physician-reported functional, and mental health recovery was good for both nonhospitalized and hospitalized patients. Recovery was, however, less favorable for patients who had been admitted to the ICU.