Thromboinflammation in Brain Ischemia: Recent Updates and Future Perspectives. Issue 5 (1st April 2022)

• Record Type: Journal Article
• Authors: De Meyer, Simon F.; Langhauser, Friederike; Haupeltshofer, Steffen; Kleinschnitz, Christoph; Casas, Ana I.
• Is Part Of: Stroke. Volume 53:Issue 5(2022)
• Page Start: 1487
• Page End: 1499
• Publication Date: 2022-04-01
• Subjects: inflammation -- ischemic stroke -- microglia -- thromboinflammation -- thrombosis; Cerebrovascular disease -- Periodicals; Cerebral circulation -- Periodicals; 616.81
• DOI: 10.1161/STROKEAHA.122.038733
• Languages: English
• ISSNs: 0039-2499

Abstract

Abstract : Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal damage following the ischemic event. Hence, we here review the most recent updates on thromboinflammatory-dependent mediators relevant after stroke focusing on recent discoveries on platelet modulation, a potential regulation of the innate and adaptive immune system in thromboinflammation, utterly providing a thorough up-to-date overview of all therapeutic approaches currently undergoing clinical trial.