Novel human metapneumovirus with a 180-nucleotide duplication in the G gene. (June 2017)

• Record Type: Journal Article
• Authors: Piñana, María; Vila, Jorgina; Gimferrer, Laura; Valls, María; Andrés, Cristina; Codina, María Gema; Ramón, Javier; Martín, María Carmen; Fuentes, Francisco; Saiz, Rosario; Alcubilla, Pilar; Rodrigo, Carlos; Pumarola, Tomàs; Antón, Andrés
• Is Part Of: Future microbiology. Volume 12:Number 7(2017)
• Page Start: 565
• Page End: 571
• Publication Date: 2017-06
• Subjects: duplication -- evolution -- genetic diversity -- genotype -- G protein -- human metapneumovirus -- molecular epidemiology -- respiratory tract infection -- respiratory virus -- surveillance; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb-2016-0211
• Languages: English
• ISSNs: 1746-0913

Abstract

Aim: To describe the circulation, genetic diversity and clinical features of human metapneumovirus (HMPV) in pediatric patients that attended the Hospital Universitari Vall d'Hebron, Spain from 2014 to 2016.Materials & methods: Partial G gene was sequenced from laboratory-confirmed HMPV respiratory specimens for subsequent phylogenetic analysis.Results: A total of 121 different samples were HMPV laboratory-confirmed out of 6658 specimens received. The highest circulation was from February to April, with a prevalence of 3%. Different genetic groups within both genotypes were detected at variable levels. A 180-nucleotide duplication was first characterized within the G gene in nine cases, mostly related to lower respiratory-tract infection.Conclusion: This study reported on the circulation of a novel HMPV with a 180-nucleotide duplication in the G gene, but no clinical changes in related cases were observed. Their prevalence increased during the last season suggesting changes in viral features.