Identification and evaluation of lncRNA and mRNA integrative modules in human peripheral blood mononuclear cells. (July 2017)

• Record Type: Journal Article
• Authors: Mo, Xing-Bo; Wu, Long-Fei; Zhu, Xiao-Wei; Xia, Wei; Wang, Lan; He, Pei; Bing, Peng-Fei; Lu, Xin; Zhang, Yong-Hong; Deng, Fei-Yan; Lei, Shu-Feng
• Is Part Of: Epigenomics. Volume 9:Number 7(2017)
• Page Start: 943
• Page End: 954
• Publication Date: 2017-07
• Subjects: cancer -- co-expression -- functional enrichment -- integrative -- lncRNA -- module -- PBMC -- UCA1 -- weighted gene co-expression network; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi-2016-0178
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: To identify sets of functionally related long noncoding RNAs (lncRNAs) and mRNAs and to evaluate the importance of lncRNAs in an lncRNA–mRNA network.Methods: We carried out weighted gene co-expression network analysis and enrichment analyses to identify functional modules of co-expressed lncRNAs and mRNAs in human peripheral blood mononuclear cells of 43 females.Results: We identified seven modules and found hub lncRNAs in each module. Four of the seven modules had significant gene ontology enrichments. Some of the hub lncRNAs (e.g., SSX8, UCA1, HOXA-AS2, STARD4-AS1 and PCBP1-AS1 ) have known functions related with diseases such as cancers.Conclusion: We identified seven biologically important lncRNA and mRNA integrative modules in females and showed that lncRNAs might play important roles in lncRNA–mRNA co-expression modules.