Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy. Issue 6 (16th June 2022)

• Record Type: Journal Article
• Authors: Nayak, Digant; Wasmuth, Elizabeth V.; Olsen, Shaun K.
• Is Part Of: Cell chemical biology. Volume 29:Issue 6(2022)
• Page Start: 927
• Page End: 929
• Publication Date: 2022-06-16
• Subjects: Biochemistry -- Periodicals; 572.05
• DOI: 10.1016/j.chembiol.2022.05.011
• Languages: English
• ISSNs: 2451-9456

Abstract

Abstract : In this issue of Cell Chemical Biology, Douglas et al. describe a potent, specific, and cell-permeable furin inhibitor that interacts with a cryptic binding site to rescue hallmarks of cystic fibrosis in human ex vivo models. BOS-318 holds promise for development of therapeutics targeting an array of furin-dependent pathologies. Abstract : In this issue of Cell Chemical Biology, Douglas et al. describe a potent, specific, and cell-permeable furin inhibitor that interacts with a cryptic binding site to rescue hallmarks of cystic fibrosis in human ex vivo models. BOS-318 holds promise for development of therapeutics targeting an array of furin-dependent pathologies.