Epidemiology and prediction of multidrug-resistant bacteria based on hospital level. (June 2022)

• Record Type: Journal Article
• Authors: Chen, Ying; Chen, Xingchi; Liang, Zheng; Fan, Shuhao; Gao, Xiaoli; Jia, Hansi; Li, Bin; Shi, Liang; Zhai, Aixia; Wu, Chao
• Is Part Of: Journal of global antimicrobial resistance. Volume 29(2022)
• Page Start: 155
• Page End: 162
• Publication Date: 2022-06
• Subjects: Multidrug resistance -- Bacteria -- Prediction -- Hospital -- Trend; Drug resistance -- Periodicals; Drug resistance -- Periodicals; Drug resistance; Periodicals; 616.9041
• DOI: 10.1016/j.jgar.2022.03.003
• Languages: English
• ISSNs: 2213-7165

Abstract

Highlights: Monthly hospital report data were used to identify indicators that are highly correlated with and predictive of multidrug-resistant bacteria (MDRB) infection. The number of hospitalised patients who received emergency rescues and rate of rational perioperative antimicrobial drug use were correlated with the number of patients with MDRB infection after 1 to 2 months. An early warning platform for patients with MDRB infection can be built using these monthly predictive indicators and their thresholds. Predictive indicators include the number of hospitalised operations, the number of patients visited the community health services centers, the number of hospitalised patients who received emergency rescues, the rate of clinical pathways, and the number of discharged patients. ABSTRACT: Objectives: Multidrug-resistant bacteria (MDRB) result in nosocomial infections and a substantial disease burden for hospitalised patients worldwide. However, strategies to control drug resistance at the hospital level are lacking. In this study, we aimed to find important indicators for risk assessment and predicting MDRB infections in the hospital. Methods: Using real-world data and machine learning models, we conducted a retrospective study from 2010 to 2020 in a teaching hospital to analyse the trends and characteristics of MDRB infections. Combining 39 hospital indicators, we used a random forest model and cross-correlation analysis to explore the important factors affecting MDRB and their predictive power. We built a decision tree model to predict the number of hospitalised patients with MDRB infection. Results: The number of hospitalised rescues and rate of rational perioperative antibacterial drug use in type I and II incision operations were correlated with the number of patients with MDRB infection after 1–2 months. The number of hospitalised operations and rate of antibiotics use in emergency patients had an effect on current MDRB-susceptible patients. The indicators, including hospital operation volume and antibacterial drug use, had a positive or negative quantitative relationship with the number of patients with MDRB infection, and their thresholds could be fit to the MDRB prediction model. Conclusion: Surgical, emergency, and hospitalised rescue patients showed the highest risk of MDRB infection. Standardised indicators such as clinical pathway rate and rational antibiotic use rate could be used to control the development and spread of MDRB infections in the hospital.