Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10). Issue 2 (8th October 2020)

• Record Type: Journal Article
• Authors: Horio, Tomohiro; Enomoto, Megumi; Watarai, Masaya; Nakano, Yuuta; Yamada, Saki; Matsumura, Saori; Kanasugi, Jo; Takasugi, Soichi; Nakamura, Ayano; Uchino, Kaori; Mizuno, Shohei; Murakami, Satsuki; Yamamoto, Hidesuke; Hanamura, Ichiro; Takami, Akiyoshi
• Is Part Of: EJHaem. Volume 1:Issue 2(2020)
• Page Start: 558
• Page End: 562
• Publication Date: 2020-10-08
• Subjects: cytogenetics -- DNA mutation -- MDS; Hematology -- Periodicals; 616.15
• DOI: 10.1002/jha2.115
• Languages: English
• ISSNs: 2688-6146

Abstract

Abstract: Unbalanced translocation der(1;7)(q10;p10) is a characteristic chromosomal abnormality in myelodysplastic syndrome (MDS). The current study revealed that among 13 MDS patients with der(1;7)(q10;p10), seven cases with no apparent dysplasia also had low numbers of myeloblasts in the bone marrow and a 3‐year survival rate of 86%; in contrast, the remaining six cases had a 3‐year survival rate of 0% ( P = .003). It was therefore suggested that MDS patients with der(1;7)(q10;p10) are classified into a distinct group with a favorable prognosis and another distinct group with a very poor prognosis.