Ag+‐Coupled Black Phosphorus Vesicles with Emerging NIR‐II Photoacoustic Imaging Performance for Cancer Immune‐Dynamic Therapy and Fast Wound Healing. (30th September 2020)

• Record Type: Journal Article
• Authors: Li, Zhi; Fu, Qinrui; Ye, Jiamin; Ge, Xiaoguang; Wang, Jie; Song, Jibin; Yang, Huanghao
• Is Part Of: Angewandte Chemie. Volume 132:Number 49(2020)
• Page Start: 22386
• Page End: 22393
• Publication Date: 2020-09-30
• Subjects: black phosphorus -- cancer therapy -- photoacoustic imaging -- second near-infrared window -- wound healing; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202009609
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: A silver‐ion‐coupled black phosphorus (BP) vesicle (BP Ve‐Ag + ) with a second near infrared (NIR‐II) window photoacoustic (PA) imaging capability was firstly constructed to maximize the potential of BP quantum dot (QD) in deeper bioimaging and diversified therapy. The embedded Ag + could improve the relatively large band gap of BP QD via intense charge coupling based on theoretical simulation results, subsequently leading to the enhanced optical absorption capability, accompanied with the occurrence of the strong NIR‐II PA signal. Guiding by NIR‐II PA bioimaging, the hidden Ag + could be precisely released with the disassembly of Ve during photodynamic therapy process and captured by macrophages located in lesion region for arousing synergistic cancer photodynamic/Ag + immunotherapy. BP Ve‐Ag + can contrapuntally kill pathogenic bacteria and accelerate wound healing monitored by NIR‐II PA imaging. Abstract : An Ag + coupled black phosphorus vesicle (BP Ve‐Ag + ) was assembled from black phosphorus quantum dots (BP QDs) and simultaneously accommodated with Ag + . The optical absorption ability of BP Ve‐Ag + in second near infrared (NIR‐II) region was significantly enhanced, which benefited from the intense charge coupling between BP QD and Ag + .