Cancer Cell Membrane Camouflaged Semi‐Yolk@Spiky‐Shell Nanomotor for Enhanced Cell Adhesion and Synergistic Therapy. Issue 39 (2nd September 2020)

• Record Type: Journal Article
• Authors: Zhou, Mengyun; Xing, Yi; Li, Xiaoyu; Du, Xin; Xu, Tailin; Zhang, Xueji
• Is Part Of: Small. Volume 16:Issue 39(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-09-02
• Subjects: biomimetic nanomotors -- cancer cell membrane coating -- cell adhesion -- chemotherapy -- NIR light‐propulsion -- photothermal therapy -- semi‐yolk spiky‐shell structure; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202003834
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Cell adhesion of nanosystems is significant for efficient cellular uptake and drug delivery in cancer therapy. Herein, a near‐infrared (NIR) light‐driven biomimetic nanomotor is reported to achieve the improved cell adhesion and cellular uptake for synergistic photothermal and chemotherapy of breast cancer. The nanomotor is composed of carbon@silica (C@SiO2 ) with semi‐yolk@spiky‐shell structure, loaded with the anticancer drug doxorubicin (DOX) and camouflaged with MCF‐7 breast cancer cell membrane (i.e., mC@SiO2 @DOX). Such biomimetic mC@SiO2 @DOX nanomotors display efficient self‐thermophoretic propulsion due to a thermal gradient generated by asymmetrically spatial distribution. Moreover, the MCF‐7 cancer cell membrane coating can remarkably reduce the bioadhesion of nanomotors in biological medium and exhibit highly specific self‐recognition of the source cell line. The combination of effective propulsion and homologous targeting dramatically improves cell adhesion and the resultant cellular uptake efficiency in vitro from 26.2% to 67.5%. Therefore, the biomimetic mC@SiO2 @DOX displays excellent synergistic photothermal and chemotherapy with over 91% MCF‐7 cell growth inhibition rate. Such smart design of the fuel‐free, NIR light‐powered biomimetic nanomotor may pave the way for the application of self‐propelled nanomotors in biomedicine. Abstract : A near‐infrared (NIR) light‐driven carbon@silica nanomotor with semi‐yolk@spiky‐shell structure loaded with doxorubicin and camouflaged with MCF‐7 cancer cell membrane is constructed. The asymmetric carbon core forms a thermal gradient under NIR light irradiation, which propels nanomotors by self‐thermophoretic force. The biomimetic nanomotor reduces the bioadhesion, but promotes cell adhesion, thus enhancing synergistic photothermal and chemotherapy of breast cancer.