Long acting porcine sequence ACTH in the diagnosis of adrenal insufficiency. Issue 6 (December 2019)

• Record Type: Journal Article
• Authors: Nair, Abilash; Jayakumari, Chellamma; George, Geena Susan; Jabbar, Puthiyaveettil Khadar; Das, Darvin V; Jessy, S J; Aneesh, T S
• Is Part Of: European journal of endocrinology. Volume 181:Issue 6(2019)
• Page Start: 639
• Page End: 645
• Publication Date: 2019-12
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1530/EJE-19-0558
• Languages: English
• ISSNs: 0804-4643

Abstract

Abstract : Objectives: Injectable tetracosactide hexa-acetate, ACTH 1-24 (Synacthen), is not marketed in many countries including India, whereas Injectable long acting porcine sequence, ACTH 1-39 (Acton Prolongatum ® ) is easily available and much cheaper. This study aimed to find the diagnostic accuracy of ACTH stimulation test using i.m. Acton Prolongatum ® (acton prolongatum stimulation test, APST) in comparison with Synacthen (short synacthen test, SST) for the diagnosis of glucocorticoid insufficiency. Methods: Subjects with a suspicion of adrenal insufficiency based on clinical features underwent a SST with 250 µg Synacthen followed by APST using 30 units of Acton Prolongatum ® . Serum cortisol levels were measured at 60 and 120 min following injection of Acton Prolongatum ® . Stimulated peak cortisol of less than 18 µg/dL on SST was considered as adrenal insufficiency. Results: Forty seven patients with mean age of 36.7 ± 14.4 years were enrolled for the study. Based on SST, twenty ( n = 20) persons were classified as having adrenal insufficiency, whereas twenty-seven ( n = 27) were found to be normal. Area under the curve of APST (at 120 min) was 0.986 when compared to SST, thus proving its high accuracy. A serum cortisol cut off value of 19.5 µg/dL at 120-min following stimulation with Acton Prolongatum ® showed a sensitivity of 100% and specificity of 88%. Conclusion: ACTH stimulation test using Acton Prolongatum ® is an economical and accurate alternative to the short Synacthen test.