A new methodology for the in vivo estimation of the elastic constants that characterize the patient-specific biomechanical behavior of the human cornea. Issue 1 (2nd January 2015)

• Record Type: Journal Article
• Authors: Lago, M.A.; Rupérez, M.J.; Martínez-Martínez, F.; Monserrat, C.; Larra, E.; Güell, J.L.; Peris-Martínez, C.
• Is Part Of: Journal of biomechanics. Volume 48:Issue 1(2015)
• Page Start: 38
• Page End: 43
• Publication Date: 2015-01-02
• Subjects: Biomechanical characterization -- Parameter optimization -- Cornea; Animal mechanics -- Periodicals; Biomechanics -- Periodicals; Biomechanics -- Periodicals; Mécanique animale -- Périodiques; Biomécanique -- Périodiques; Electronic journals; 571.4305
• DOI: 10.1016/j.jbiomech.2014.11.009
• Languages: English
• ISSNs: 0021-9290

Abstract

Abstract: This work presents a methodology for the in vivo characterization of the complete biomechanical behavior of the human cornea of each patient. Specifically, the elastic constants of a hyperelastic, second-order Ogden model were estimated for 24 corneas corresponding to 12 patients. The finite element method was applied to simulate the deformation of human corneas due to non-contact tonometry, and an iterative search controlled by a genetic heuristic was used to estimate the elastic parameters that most closely approximates the simulated deformation to the real one. The results from a synthetic experiment showed that these parameters can be estimated with an error of about 5%. The results of 24 in vivo corneas showed an overlap of about 90% between simulation and real deformed cornea and a modified Hausdorff distance of 25 μm, which indicates the great accuracy of the proposed methodology.