Stimuli-sensitive drug delivery systems for site-specific antibiotic release. Issue 6 (June 2022)

• Record Type: Journal Article
• Authors: Nazir, Faiqa; Tabish, Tanveer A.; Tariq, Fatima; Iftikhar, Shanza; Wasim, Rijja; Shahnaz, Gul
• Is Part Of: Drug discovery today. Volume 27:Issue 6(2022)
• Page Start: 1698
• Page End: 1705
• Publication Date: 2022-06
• Subjects: External stimuli-responsive drug delivery -- Internal stimuli-responsive drug delivery -- Targeted drug delivery -- Antibiotic release -- Nanoparticles; Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2022.02.014
• Languages: English
• ISSNs: 1359-6446

Abstract

Highlights: The stimuli leading to drug release can be either external or internal. Nanoparticles are promising agents for targeted stimuli-dependent antibiotic drugs delivery. Targeted antibiotic release at desired site minimizes the resistance and side effects associated with systematic release of drug(s). Abstract: Site-specific delivery of antibiotics has always been a high-priority area in pharmaceutical research. Conventionally used antibiotics suffer several limitations, such as low accumulation and penetration in diseased cells/tissues, limited bioavailability of drugs, drug resistance, and off-target toxicity. To overcome these limitations, several strategies have been exploited for delivering antibiotics to the site of infection, such as the use of stimuli-responsive antibiotic delivery systems, which can release antibiotics in a controlled and timely fashion. These stimuli can either be exogenous (light, magnetism, ultrasound, and electrical) or endogenous (pH, redox reactions, and enzymatic). In this review, we present a summary of recent developments in the field of stimuli-based targeted drug delivery systems for the site-specific release of antibiotics.