Metal- and additive-free direct C3-aminomethylation of imidazo[1, 2–a]pyridines with 1, 3, 5-triazinanes. (11th May 2022)

• Record Type: Journal Article
• Authors: Feng, Zongbo; Deng, Lin; Wei, Jianwei; Wu, Yingqi; Jiang, Zhimin; Wang, Yuanxiang
• Is Part Of: Tetrahedron letters. Volume 97(2022)
• Publication Date: 2022-05-11
• Subjects: Metal- and additive-free -- Aminomethylation -- Imidazo -- 2–a]pyridine -- 1 -- 3 -- 5-Triazinane; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153790
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: An efficient C3-aminomethylation of imidazo[1, 2– a ]pyridines with 1, 3, 5-triazinanes was developed. The eminent advantage of this work is catalyst-free and additive-free. Abstract: An efficient C3-aminomethylation of imidazo[1, 2– a ]pyridines with 1, 3, 5-triazinanes was developed. The eminent advantage of this work is catalyst-free and additive-free. The power of this transformation has been demonstrated by the broad substrate scope and good functional group tolerance.