Prognostic value of left ventricular blood stasis in patients with acute myocardial infarction: A cardiac magnetic resonance study. (1st July 2022)

• Record Type: Journal Article
• Authors: Massussi, Mauro; Cipriani, Alberto; Meneghin, Samuele; De la Cruz, Nicola; Cecere, Annagrazia; D'Amico, Gianpiero; Cacciavillani, Luisa; De Conti, Giorgio; Motta, Raffaella; Tarantini, Giuseppe; Zorzi, Alessandro; Iliceto, Sabino; De Lazzari, Manuel; Perazzolo Marra, Martina
• Is Part Of: International journal of cardiology. Volume 358(2022)
• Page Start: 128
• Page End: 133
• Publication Date: 2022-07-01
• Subjects: Blood stasis -- Cardiac magnetic resonance -- Ischemic stroke; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2022.04.012
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Cerebrovascular accidents (CVAs) can complicate the follow-up of patients with acute myocardial infarction (AMI). Intracavitary blood stasis evaluation can be useful to stratify cardioembolic risk and optimize medical therapy. Cardiac magnetic resonance (CMR) imaging is increasingly used in AMI patients for prognostic purposes. Slow-flow artefact is common on T2-weighted images in presence of left ventricular (LV) blood stasis. Methods and results: In this observational retrospective study, all patients with AMI undergoing CMR in our hospital were included. T2-weighted images were used to assess the presence of LV blood stasis. Among the 209 patients enrolled (males 72%, mean age 61 ± 12 years), LV blood stasis was detected in 48 (23%) and was significantly more prevalent in patients with extensive anterior or antero-apical AMI, lower LV ejection fraction, greater infarct size and microvascular obstruction. During follow-up (54 months, IQR 41–70), 8 CVAs and 6 cardiovascular deaths occurred. LV blood stasis emerged as a significant risk factor for both endpoints (logRank p < 0.001 and p = 0.008, respectively) and remained independent predictor of CVAs (HR 9.819, 95% CI 1.733–55.617, p = 0.010). Conclusions: LV blood stasis identified with CMR predicts the occurrence of CVAs in patients with AMI. These results may be helpful to personalize antithrombotic therapy for prevention strategies. Highlights: Cerebrovascular accidents can complicate the follow-up of patients with acute myocardial infarction. CMR imaging is increasingly used in patients suffering from acute myocardial infarction for prognostic purposes. LV blood stasis identified with CMR predicts the occurrence of CVAs in patients with acute myocardial infarction.