Synthesis of 1H-isoindoliums by electrophile-mediated cascade cyclization/iodination of propargylamine-based 1, 6-diynes. Issue 18 (14th April 2022) - Cui, Jian-Fang
Abstract : A highly regio- and chemoselective synthesis of 1 H -isoindoliums through a novel cascade cyclization reaction of propargylamine-based 1, 6-diynes has been developed. Abstract : A highly regio- and chemoselective synthesis of 1 H -isoindoliums through a facile and novel cascade cyclization reaction of propargylamine-based 1, 6-diynes under mild conditions has been developed. Different functional groups were compatible under the optimized reaction conditions, giving the corresponding products in up to 94% yields. Upon treatment with a base, the alkyne moiety of 1 H -isoindoliums could be further transformed to allenes in excellent yields.