Quinolizinium-based fluorescent probes for formaldehyde detection in aqueous solution, serum, and test strip via 2-aza-Cope rearrangement. Issue 18 (13th April 2022)

• Record Type: Journal Article
• Authors: Tantipanjaporn, Ajcharapan; Ka-Yan Kung, Karen; Sit, Hoi-Yi; Wong, Man-Kin
• Is Part Of: RSC advances. Volume 12:Issue 18(2022)
• Page Start: 11543
• Page End: 11547
• Publication Date: 2022-04-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra01397e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Novel quinolizinium-based fluorescent probes were designed based on 2-aza-Cope rearrangement reaction to detect formaldehyde in aqueous solution, serum, and paper format. The use of a geminal dimethyl group allows fast response within 15 min. Abstract : Formaldehyde is an abundant contaminant in food and environments causing various diseases. Thus, the development of fast, simple, and selective formaldehyde detection is of great interest. Herein, novel quinolizinium-based fluorescent probes were designed based on a 2-aza-Cope rearrangement reaction and showed high selectivity to formaldehyde by fluorescence emission shift. We successfully reduced the detection time by increasing the bulkiness of the homoallylic moiety. The probes were applied to detect formaldehyde in aqueous solution, serum, and paper format.