Chemoenzymatic total synthesis of nodulones C and D using a naphthol reductase of Magnaporthe grisea. Issue 18 (25th April 2022)

• Record Type: Journal Article
• Authors: Manna, Tanaya; Rajput, Anshul; Saha, Nirmal; Mondal, Amit; Debnath, Subhas Chandra; Husain, Syed Masood
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 18(2022)
• Page Start: 3737
• Page End: 3741
• Publication Date: 2022-04-25
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob00401a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Herein, the asymmetric and chemoenzymatic synthesis of ( R )-nodulone C, cis -nodulone D and related ( R )-dihydronaphthalenone is reported. Abstract : Herein, the asymmetric and chemoenzymatic synthesis of ( R )-nodulone C, cis -nodulone D and related ( R )-dihydronaphthalenone is reported. It involves multistep chemical synthesis of putative biosynthetic substrates followed by regio- and stereoselective reduction using a NADPH-dependent tetrahydroxynaphthalene reductase of Magnaporthe grisea to obtain chiral nodulones in a biomimetic fashion.