An unexpected photoinduced cyclization to synthesize fully substituted γ-spirolactones via intramolecular hydrogen abstraction with allyl acrylates. Issue 9 (1st March 2022) - Sun, Xin
Abstract : A photoinduced intramolecular cyclization of allyl acrylates to synthesize fully substituted spiro-γ-butyrolactone compounds is described. The reaction is believed to proceed through an intramolecular hydrogen abstraction strategy. Abstract : A photoinduced intramolecular cyclization of allyl acrylates to synthesize fully substituted spiro-γ-butyrolactone compounds is described. The reaction is believed to proceed through activation of the carbonyl group upon ultraviolet irradiation, 1, 4-hydrogen atom transfer, and intramolecular cyclization of diradical species, an intramolecular hydrogen abstraction strategy, based on a series of control and isotope studies as well as DFT calculations.