A review on lawsone-based benzo[a]phenazin-5-ol: synthetic approaches and reactions. Issue 22 (9th May 2022)

• Record Type: Journal Article
• Authors: Olyaei, Abolfazl; Sadeghpour, Mahdieh
• Is Part Of: RSC advances. Volume 12:Issue 22(2022)
• Page Start: 13837
• Page End: 13895
• Publication Date: 2022-05-09
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d2ra02139k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Phenazine systems are an important class of aza-polycyclic compounds that are easily found in nature and isolated as secondary metabolites primarily from Pseudomonas, Streptomyces, and a few other genera from soil or marine habitats. Abstract : Phenazine systems are an important class of aza-polycyclic compounds that are easily found in nature and isolated as secondary metabolites primarily from Pseudomonas, Streptomyces, and a few other genera from soil or marine habitats. Moreover, various synthetic phenazine analogs are known for their pharmaceutical activities. Among various phenazines, benzo[ a ]phenazines are structural subunits in a variety of important natural products and have been given special attention due to their unique biological properties in various fields. In this review article, we highlight the synthesis of benzo[ a ]phenazin-5-ol derivatives from lawsone and benzene-1, 2-diamines and their applications for the construction of a variety of five and six membered fused heterocycles such as pyranophenazines, spiropyranophenazines, pyridophenazines, furophenazines, benzochromenophenazines and oxazinophenazines during the period of 1995 to 2021.