Targeting stemness of cancer stem cells to fight colorectal cancers. (July 2022)

• Record Type: Journal Article
• Authors: Du, Lei; Cheng, Qi; Zheng, Hao; Liu, Jinming; Liu, Lei; Chen, Quan
• Is Part Of: Seminars in cancer biology. Volume 82(2022)
• Page Start: 150
• Page End: 161
• Publication Date: 2022-07
• Subjects: CSC cancer stem cell -- CRC colorectal cancer -- CCSC colorectal cancer stem cell -- PrPc cellular prion protein -- EMT epithelial to mesenchymal transition -- FCM flow cytometry -- FACS fluorescence activated cell sorting -- NOD/SCID nonobese diabetic/severe combined immunodeficiency -- TME tumor microenvironment -- ABCG2 ATP Binding Cassette Subfamily G Member 2 -- LGR5 G-proteine-coupled receptor 5 -- LGR4 G-proteine-coupled receptor 4 -- CAR-T chimeric antigen receptors (CAR)- T cell -- TAA tumor associated antigen; Colorectal cancer -- Cancer stem cells -- Tumor initiating cells -- Cancer stem cell markers -- Monoclonal antibody -- Tumor organoid; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2021.02.012
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Cancer initiating/ stem cells (CSCs) undergo self-renewal and differentiation that contributes to tumor initiation, recurrence and metastasis in colorectal cancer (CRC). Targeting of colorectal cancer stem cells (CCSCs) holds significant promise in eradicating cancer cells and ultimately curing patients with cancer. In this review, we will introduce the current progress of CCSC studies, including the specific surface markers of CCSCs, the intrinsic signaling pathways that regulate the stemness and differentiation characteristics of CCSCs, and the tumor organoid model for CCSC research. We will focus on how these studies will lead to the progress in targeting specific surface markers or signaling pathways on CCSCs by monoclonal antibodies, or by natural or synthetic compounds, or by immunotherapy. As CSCs are highly heterogeneous and plastic, we suggest that combinatory approaches that target the stemness network may represent an important strategy for eradicating cancers.