Bis(4-carboxylpyrazol-1-yl)acetic acid: a scorpionate ligand for complexes with improved water solubility. Issue 17 (19th April 2022)

• Record Type: Journal Article
• Authors: Tzegai, Wintana; Reil, Michaela; Burzlaff, Nicolai
• Is Part Of: Dalton transactions. Volume 51:Issue 17(2022)
• Page Start: 6839
• Page End: 6845
• Publication Date: 2022-04-19
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d2dt00848c
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : A carboxyl-decorated bis(pyrazol-1-yl)acetic acid and carbonyl complexes derived thereof are reported. The peripheral carboxyl functionalities increase their solubility in water and especially in PBS buffer. Abstract : Bis(4-carboxylpyrazol-1-yl)acetic acid (H3 bcpza) (2 ), obtained in a one-pot synthesis, contains carboxyl groups that differ in their p K a values. The ligand exhibits heteroscorpionate κ 3 -N, N, O-coordination whereupon the peripheral carboxyl groups are not involved in metal binding. The corresponding carbonyl complexes [Mn(H2 bcpza)(CO)3 ] (4 ), [Re(H2 bcpza)(CO)3 ] (5 ) and [Ru(H2 bcpza)Cl(CO)2 ] (6a /6b ) are partially soluble in water but readily soluble in PBS buffer.