A multifunctional hydrogel dressing with antibacterial properties for effective wound healing. Issue 17 (19th April 2022)

• Record Type: Journal Article
• Authors: Zhang, Ye; Yang, Dan; Guo, Wei; Zhang, Feng; Lin, Huiming; Yu, Kai; Yang, Chunyu; Qu, Fengyu
• Is Part Of: Dalton transactions. Volume 51:Issue 17(2022)
• Page Start: 6817
• Page End: 6824
• Publication Date: 2022-04-19
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d1dt04128b
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : Silver-doped yolk-like nickel sulfide is developed as "six-in-one" multifunctional hydrogel dressing with significant potential for effective antibacterial wound healing applications. Abstract : We have developed a multifunctional hydrogel dressing (denoted as dressing-2 : 1) using silver-doped yolk-like nickel sulfide (Ag(8.5%)@NiS2− x ), polyacrylamide (PAM), and chitosan (CS). Ag(8.5%)@NiS2− x has tremendous potential in antibacterial applications mainly due to the following advantages: (i) it has excellent optical absorption in the 200–2500 nm range and can be combined with near-infrared laser for photothermal therapy; (ii) it possesses peroxidase characteristic, which can catalyze low-concentration hydrogen peroxide to produce highly effective bactericidal hydroxyl radicals; (iii) silver doping gives it the ability to destroy the inherent components of bacteria. Moreover, the PAM/CS hydrogel can adsorb both bacteria and inflammatory secretions, enhancing the sterilization ability of Ag(8.5%)@NiS2− x and promoting tissue healing. Our work highlights the great potential of dressing-2 : 1 as a multifunctional hydrogel dressing for effective antibacterial wound healing.