A cascade reaction for regioselective construction of pyrazole-containing aliphatic sulfonyl fluorides. Issue 17 (14th April 2022)

• Record Type: Journal Article
• Authors: Yang, Wen-Fei; Shu, Tao; Chen, Hong-Ru; Qin, Hua-Li; Tang, Haolin
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 17(2022)
• Page Start: 3506
• Page End: 3510
• Publication Date: 2022-04-14
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob00515h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A copper-catalyzed cascade reaction of α-diazocarbonyl compounds with ethenesulfonyl fluoride for the construction of pyrazole-containing aliphatic sulfonyl fluorides is developed. Abstract : A copper-catalyzed cascade reaction of α-diazocarbonyl compounds with ethenesulfonyl fluoride (ESF) is developed, affording a variety of highly functionalized pyrazolyl aliphatic sulfonyl fluorides in good to excellent yields (66–98%). This transformation features broad substrates, exclusive regioselectivity, high atom economy and operational simplicity, thus providing a straightforward method for the direct construction of pyrazole-containing aliphatic sulfonyl fluorides, which will provide great applicable value in medicinal chemistry and other related disciplines.