Nickel-catalyzed carbonylative domino cyclization of arylboronic acid pinacol esters with 2-alkynyl nitroarenes toward N-aroyl indoles. Issue 10 (12th April 2022)

• Record Type: Journal Article
• Authors: Yao, Lingyun; Wei, Ping; Ying, Jun; Wu, Xiao-Feng
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 10(2022)
• Page Start: 2685
• Page End: 2689
• Publication Date: 2022-04-12
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00112h
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A nickel-catalyzed carbonylative domino cyclization of arylboronic acid pinacol esters with 2-alkynyl nitroarenes has been developed. Abstract : A nickel-catalyzed carbonylative domino cyclization of arylboronic acid pinacol esters with 2-alkynyl nitroarenes has been developed. This tandem reaction proceeded well to synthesize various N -aroyl indole derivatives in moderate to high yields. Here, Co2 (CO)8 has been used as the CO source and also as the co-catalyst for the cyclization step. Control experiments were performed to gain more insights into the reaction mechanism. Notably, besides acting as a reaction partner, 2-alkynyl nitroarenes may also serve as the oxidant to regenerate the active nickel catalyst.