Relationship between the serum GDF-15 concentration and muscle function in female patients receiving aortic valve replacement (TAVR, SAVR): Comparison with healthy elderly female subjects. (June 2022)

• Record Type: Journal Article
• Authors: Fukuda, Taira; Nakajima, Toshiaki; Yazawa, Hiroko; Hirose, Suguru; Yokomachi, Jun; Kato, Takashi; Nishikawa, Riichi; Koshiji, Nobuo; Tokura, Michiaki; Nasuno, Takahisa; Nishino, Setsu; Obi, Syotaro; Shibasaki, Ikuko; Kanaya, Tomoaki; Nakamura, Fumitaka; Fukuda, Hirotsugu; Abe, Shichiro; Sakuma, Masashi; Toyoda, Shigeru
• Is Part Of: IJC heart & vasculature. Volume 40(2022)
• Publication Date: 2022-06
• Subjects: Sarcopenia -- Growth differentiation factor −15 -- Aortic valve replacement; GDF growth differentiation factor -- TAVR transcatheter aortic valve replacement -- SAVR conventional surgical aortic valve replacement -- SMI skeletal muscle mass index -- ROC receiver-operating characteristics -- eGFR estimated glomerular filtration rate -- AS aortic stenosis -- CHF chronic heart failure -- VO2 oxygen uptake -- NYHA New York Heart Association -- LVEF left ventricular ejection fraction -- TGF transforming growth factor -- hsCRP high-sensitive C-reactive protein -- ELISA enzyme-linked immunosorbent assay -- AWGS Asian Working Group for Sarcopenia -- ANOVA analysis of variance -- CFS Clinical Frailty Scale -- PAH pulmonary arterial hypertension -- BNP brain natriuretic peptide -- GH growth hormone -- TAK1 TGFβ-activated kinase 1; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Pathophysiology -- Periodicals; 616.1005
• DOI: 10.1016/j.ijcha.2022.101032
• Languages: English
• ISSNs: 2352-9067

Abstract

Abstract: Purpose: Sarcopenia is closely associated with postoperative prognosis in patients undergoing cardiovascular surgery. Growth differentiation factor (GDF)-15 is involved in the pathogenesis of cardiovascular disease. We examined the relationship between the serum GDF-15 concentration and muscle function in patients receiving aortic valve replacement and healthy elderly subjects. Methods: Forty-three female patients undergoing aortic valve surgery (79.9 ± 6.4 years; transcatheter aortic valve replacement [TAVR] n = 19, conventional surgical aortic valve replacement [SAVR] n = 24) and 64 healthy elderly female subjects (75.9 ± 6.1 years) were included. Walking speed, grip strength, and skeletal muscle mass index (SMI) by a multifrequency bioelectrical impedance analyzer were measured to determine the presence of sarcopenia. Preoperative serum GDF-15 concentration was measured by enzyme-linked immunosorbent assay. Results: The GDF-15 level was higher in patients receiving aortic valve replacement than in healthy elderly subjects (aortic valve replacement: 1624 ± 1186 pg/mL vs. healthy: 955 ± 368 pg/mL, p < 0.001). Multivariate linear regression analysis showed that the serum GDF-15 level determined grip strength independently of the high-sensitivity C-reactive protein level and eGFR, even after adjusting for age (β = -0.318, p = 0.025). Sarcopenia was found in 12.5% of healthy elderly subjects, 83.3% of patients with TAVR, and 64.3% of patients with SAVR. The GDF-15 concentration that defined sarcopenia was 1109 pg/mL in subjects including patients receiving aortic valve replacement. Conclusions: The preoperative serum GDF-15 concentration, which was higher in female patients receiving aortic valve replacement than in healthy elderly subjects, may be a serum marker of sarcopenia.