Effects of intrauterine and lactational exposure to lanthanum nitrate on BALB/c offspring mice: Developmental immunotoxicity and self-recovery. (1st June 2022)

• Record Type: Journal Article
• Authors: Wang, Xiaoyun; Tang, Mengmeng; Ge, Jianhong; Jiang, Wanyu; Li, Zekang; Xiao, Qianqian; Meng, Qinghe; Jiang, Jianjun; Hao, Weidong; Wei, Xuetao
• Is Part Of: Toxicology letters. Volume 362(2022)
• Page Start: 17
• Page End: 25
• Publication Date: 2022-06-01
• Subjects: BIM Bcl-2-like protein 11 -- ConA Concanavalin -- DIT Developmental immunotoxicity -- DTH Delayed-type hypersensitivity -- DP Double positive -- GD Gestational day -- HBSS Hanks balanced salt solution -- LN Lanthanum nitrate -- LPS Lipopolysaccharide -- LDH Lactate dehydrogenase -- MLN Mesenteric lymph nodes -- PND Postanal day -- PB Peripheral blood -- PFC Plaque-forming cell -- REE Rare earth element; Lanthanum nitrate -- Developmental immunotoxicity -- Thymus degeneration -- BALB/c mice; Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2022.01.013
• Languages: English
• ISSNs: 0378-4274

Abstract

Highlights: Lanthanum nitrate (LN) induces developmental immunotoxicity (DIT) in offspring mice. Female is more vulnerable to LN-induced DIT. The impaired adaptive immunity is difficult to be eliminated after stopping administration. LN might accelerate thymus degeneration by inducing double-positive T cells apoptosis. The LOAEL of LN for DIT is 1 mg/kg/day. Abstract: Lanthanum, a major rare earth element, can exert detrimental effects on the adult immune system, but its developmental immunotoxicity (DIT) remains obscure. This study was designed to evaluate the DIT of lanthanum nitrate (LN) and the self-recovery of LN-induced DIT 21 days following cessation of exposure. BALB/c pregnant dams were exposed to 0, 0.1, 1, and 10 mg/kg body weight/day LN by gavage during gestation and lactation. Results showed that in male offspring, LN markedly inhibited the adaptive immunity at postanal day 21 (PND21) and the inhibitory effect on cellular immunity continued to PND42 (after three weeks of self-recovery). In female offspring, LN suppressed cellular immunity at both PND21 and PND42. Moreover, decreased relative organ weight of thymus, humoral immunity and proportion of double-positive T cells in thymus were also observed at PND42. Bcl-xl protein level decreased in thymus of female at PND42, while the level of β-catenin increased. These changes might contribute to accelerating the degeneration and weight loss of thymus. Overall, in-utero and postanal exposure to LN could induce impairments of immunity in offspring, especially the female, and adaptive immunosuppression would persist throughout development into adulthood. The LOAEL of LN for DIT should be 1 mg/kg.