In vitro display evolution of unnatural peptides spontaneously cyclized via intramolecular nucleophilic aromatic substitutions. Issue 34 (7th April 2022)

• Record Type: Journal Article
• Authors: Yokoyama, Takumi; Ando, Takehiro; Takamori, Yukio; Fuji, Daisuke; Sato, Masashi; Vedi, Santhana; Yamamoto, Mizuki; Kawakami, Takashi
• Is Part Of: Chemical communications. Volume 58:Issue 34(2022)
• Page Start: 5237
• Page End: 5240
• Publication Date: 2022-04-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc00584k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We report novel spontaneous peptide cyclization by intramolecular nucleophilic aromatic substitutions using ribosomally incorporatable and intramolecularly cysteine-reactive fluorobenzoic acid-derived linkers. Abstract : We report novel, ribosomally incorporatable, and intramolecularly cysteine-reactive fluorobenzoic acid-derived linkers for SELEX of mRNA-displayed unnatural peptides, which spontaneously cyclized via intramolecular nucleophilic aromatic substitutions forming thioethers. With this strategy we identified several novel PCSK9-binding peptides.