A pH-responsive mesoporous silica nanoparticle-based drug delivery system for targeted breast cancer therapy. Issue 17 (7th April 2022)

• Record Type: Journal Article
• Authors: Chang, Jie; Mo, Liufang; Song, Jinfeng; Wang, Xiaochen; Liu, Hanhan; Meng, Chenchen; Wu, Yijun
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 17(2022)
• Page Start: 3375
• Page End: 3385
• Publication Date: 2022-04-07
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb02828f
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : MSN-COOH was synthesized and sealed DOX in the hole, then PEI and AA were modified to the surface of MSN-COOH through amide bonds. This delivery system could achieve pH-responsive drug release and targeted drug delivery simultaneously. Abstract : In order to make the drug specifically aggregate at the tumor site, we had developed a targeted drug delivery system based on pH responsive mesoporous silica nanoparticles. Mesoporous silica nanoparticles (MSN-COOH) were prepared and doxorubicin (DOX) was loaded into the pores of MSN-COOH, and then polyethyleneimine (PEI) and anisamide (AA) were modified on the surface of mesoporous silica, named DOX@MSN-PEI-AA(DMPA). DMPA specifically entered tumor cells through AA-mediated receptor endocytosis; PEI dissociated from the surface of the MSN in the acidic environment of cellular lysosomes/endosomes due to protonation of PEI, resulting in steady release of the encapsulated DOX from the pores of MSN in the cytoplasm of the target cells. In vitro and in vivo anti-tumor experiments and hemolytic experiments indicated that DMPA can accurately target breast cancer cells and show excellent safety at the same time, showing great potential for tumor therapy.