Dual-imaging magnetic nanocatalysis based on Fenton-like reaction for tumor therapy. Issue 18 (11th April 2022)

• Record Type: Journal Article
• Authors: Zhou, Weicheng; Tang, Xinyi; Huang, Ju; Wang, Jingxue; Zhao, Jiawen; Zhang, Liang; Wang, Zhigang; Li, Pan; Li, Rui
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 18(2022)
• Page Start: 3462
• Page End: 3473
• Publication Date: 2022-04-11
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb02308j
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Sequential nano-catalytic therapy has emerged as a novel therapeutic modality for cancer treatment as it utilizes the unique tumor microenvironment for selective tumor treatment. Abstract : Sequential nano-catalytic therapy has emerged as a novel therapeutic modality for cancer treatment as it utilizes the unique tumor microenvironment for selective tumor treatment. This study reports a magnetic nanoparticle to achieve Fenton-like reaction and dual-imaging guidance/monitoring. Natural glucose oxidase (GOx) and superparamagnetic Fe3 O4 nanoparticles have been integrated into poly(lactic- co -glycolic acid) (PLGA) to fabricate a sequential nanocatalyst (designated as GOx@PLGA-Fe3 O4 ). This nanocatalyst can functionally deplete glucose in tumor tissues, producing a considerable amount of highly cytotoxic hydroxyl radicals via the sequential Fenton-like reaction, and meanwhile maximizing the potential imaging capability as a contrast agent for magnetic resonance imaging and photoacoustic imaging. By ribonucleic acid sequencing (RNA-seq) technology, GOx@PLGA-Fe3 O4 nanoparticles are demonstrated to induce tumor cell death by inhibiting multiple gene regulation pathways involving tumor growth and recurrence. Therefore, this finding provides a novel strategy to achieve promising therapeutic efficacy by the rational design of multifunctional nanoparticles with various features, including magnetic targeting, sequential nano-catalytic therapy, and dual-imaging guidance/monitoring.