DLSSAffinity: protein–ligand binding affinity prediction via a deep learning model. Issue 17 (13th April 2022)

• Record Type: Journal Article
• Authors: Wang, Huiwen; Liu, Haoquan; Ning, Shangbo; Zeng, Chengwei; Zhao, Yunjie
• Is Part Of: Physical chemistry chemical physics. Volume 24:Issue 17(2022)
• Page Start: 10124
• Page End: 10133
• Publication Date: 2022-04-13
• Subjects: Chemistry, Physical and theoretical -- Periodicals; 541.3
• DOI: 10.1039/d1cp05558e
• Languages: English
• ISSNs: 1463-9076

Abstract

Abstract : We propose a novel deep learning-based approach, DLSSAffinity, to accurately predict protein–ligand binding affinity. We show that combining global sequence and local structure information as the input features of a deep learning model can improve the prediction accuracy. Abstract : Evaluating the protein–ligand binding affinity is a substantial part of the computer-aided drug discovery process. Most of the proposed computational methods predict protein–ligand binding affinity using either limited full-length protein 3D structures or simple full-length protein sequences as the input features. Thus, protein–ligand binding affinity prediction remains a fundamental challenge in drug discovery. In this study, we proposed a novel deep learning-based approach, DLSSAffinity, to accurately predict the protein–ligand binding affinity. Unlike the existing methods, DLSSAffinity uses the pocket–ligand structural pairs as the local information to predict short-range direct interactions. Besides, DLSSAffinity also uses the full-length protein sequence and ligand SMILES as the global information to predict long-range indirect interactions. We tested DLSSAffinity on the PDBbind benchmark. The results showed that DLSSAffinity achieves Pearson's R = 0.79, RMSE = 1.40, and SD = 1.35 on the test set. Comparing DLSSAffinity with the existing state-of-the-art deep learning-based binding affinity prediction methods, the DLSSAffinity model outperforms other models. These results demonstrate that combining global sequence and local structure information as the input features of a deep learning model can improve the accuracy of protein–ligand binding affinity prediction.