Cancer in sub-Saharan Africa in 2020: a review of current estimates of the national burden, data gaps, and future needs. Issue 6 (June 2022)

• Record Type: Journal Article
• Authors: Bray, Freddie; Parkin, D Maxwell; Gnangnon, Freddy; Tshisimogo, Gontse; Peko, Jean-Felix; Adoubi, Innocent; Assefa, Mathewos; Bojang, Lamin; Awuah, Baffour; Koulibaly, Moussa; Buziba, Nathan; Korir, Anne; Dzamalala, Charles; Kamate, Bakarou; Manraj, Shyam; Ferro, Josefo; Lorenzoni, Cesaltina; Hansen, Rolf; Nouhou, Hassan; Ogunbiyi, Olufemi; Igbinoba, Festus; Ekanem, Ima; Omonisi, Abidemi; Chirpaz, Emmanuel; Uwinkindi, Francois; Finesse, Anne; Somdyala, Ntuthu; Singh, Elvira; Dlamini, Xolisilie; Masalu, Nestory; Serventi, Furaha; Mrema, Caroline; Wabinga, Henry; Ogwang, Martin; Chiwele, Linda; Borok, Margaret; Chingonzoh, Tatenda;
• Is Part Of: Lancet oncology. Volume 23:Issue 6(2022)
• Page Start: 719
• Page End: 728
• Publication Date: 2022-06
• Subjects: Oncology -- Periodicals; Neoplasms -- Periodicals; Cancérologie -- Périodiques; Oncologie; Oncology; Periodicals; Electronic journals; 616.994005
• DOI: 10.1016/S1470-2045(22)00270-4
• Languages: English
• ISSNs: 1470-2045

Abstract

Summary: Background: With the cancer burden rising in sub-Saharan Africa, countries in the region need surveillance systems to measure the magnitude of the problem and monitor progress in cancer control planning. Based on the national estimates built from data provided by cancer registries in sub-Saharan Africa, we summarise key patterns of the regional burden and argue for investments in locally produced data. Methods: To present national estimates of the cancer incidence and mortality burden in sub-Saharan Africa countries, new cancer cases and deaths were extracted from International Agency for Research on Cancers' GLOBOCAN database for the year 2020. Given weak vital statistics systems, almost all of the information on the cancer burden in sub-Saharan Africa was derived from population-based cancer registries. Of the 48 countries included in GLOBOCAN (national populations must be larger than 150 000 inhabitants in 2020), relatively recent cancer registry data (up to 2019) were directly used to produce national incidence estimates in 25 countries, while the absence of such data for 16 meant that estimates were based on data from neighbouring countries. Tables and figures present the estimated numbers of new cases and deaths, as well as age-standardised (incidence or mortality) rates per 100 000 person-years and the cumulative risk of developing or dying from cancer before the age of 75 years. Findings: 801 392 new cancer cases and 520 158 cancer deaths were estimated to have occurred in sub-Saharan Africa in 2020. Cancers of the breast (129 400 female cases) and cervix (110 300 cases) were responsible for three in ten of the cancers diagnosed in both sexes. Breast and cervical cancer were the most common cancers, ranking first in 28 and 19 countries, respectively. In men, prostate cancer led in terms of incidence (77 300 cases), followed by liver cancer (24 700 cases) and colorectal cancer (23 400 cases). Prostate cancer was the leading incident cancer in men in 40 sub-Saharan Africa countries. The risk of a woman in sub-Saharan Africa developing cancer by the age of 75 years was 14·1%, with breast cancer (4·1%) and cervical cancer (3·5%) responsible for half of this risk. For men, the corresponding cumulative incidence was lower (12·2%), with prostate cancer responsible for a third of this risk (4·2%). Cervical cancer was the leading form of cancer death among women in 27 countries, followed by breast cancer (21 countries). Prostate cancer led as the most common type of cancer death in 26 countries, with liver cancer ranking second (11 countries). Interpretation: The estimates indicate substantial geographical variations in the major cancers in sub-Saharan Africa. Rational cancer control planning requires capacity to be built for data production, analysis, and interpretation within the countries themselves. Cancer registries provide important information in this respect and should be prioritised for sustainable investment in the region. Funding: None.