Mn(iii)-Catalyzed cascade cyclization reaction of o-acyl aromatic isocyanides with boronic acids. Issue 9 (29th March 2022)

• Record Type: Journal Article
• Authors: Liu, Jingya; Li, Lei; Bu, Xiubin; Yuan, Yu; Wang, Xin; Sun, Ran; Zhou, Ming-Dong; Wang, He
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 9(2022)
• Page Start: 2486
• Page End: 2490
• Publication Date: 2022-03-29
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00271j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A Mn(iii )-catalyzed cascade cyclization of o -acyl aromatic isocyanides with boronic acids was examined to give a series of 3-hydroxyindolenines in single-step. This cascade process involved a transmetalation/nucleophilic addition/intramolecular cyclization sequence. Abstract : A Mn(iii )-catalyzed cascade cyclization of o -acyl aromatic isocyanides with boronic acids was carried out via a single-step route to generate a series of 3-hydroxyindolenines under mild conditions. A plausible mechanism involving a cascade transmetalation, nucleophilic addition and intramolecular cyclization sequence was proposed and confirmed. In addition, the reaction procedure featured simple synthesis, wide substrate scope, and excellent functional group compatibility.