Real-time drug release monitoring from pH-responsive CuS-encapsulated metal–organic frameworks. Issue 18 (8th April 2022)

• Record Type: Journal Article
• Authors: Liu, Bei; Sun, Lirong; Lu, Xijian; Yang, Yuping; Peng, Hongshang; Sun, Zhaogang; Xu, Juan; Chu, Hongqian
• Is Part Of: RSC advances. Volume 12:Issue 18(2022)
• Page Start: 11119
• Page End: 11127
• Publication Date: 2022-04-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1ra09320g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A metal–organic framework-based nanotheranostic system was fabricated to achieve the capabilities of tumor-targeting, real-time monitoring of pH-responsive drug release and combined chemo-photothermal therapy. Abstract : Real-time monitoring of drug release behaviors over extended periods of time is critical in understanding the dynamics of drug progression for personalized chemotherapeutic treatment. In this work, we report a metal–organic framework (MOF)-based nanotheranostic system encapsulated with photothermal agents (CuS) and therapeutic drug (DOX) to achieve the capabilities of real-time drug release monitoring and combined chemo-photothermal therapy. Meanwhile, folic acid-conjugated polyethylene glycol (FA-PEG) antennas were connected to the MOF through coordination interactions, endowing the MOF with an enhanced active targeting effect toward cancer cells. It is anticipated that such a theranostic agent, simultaneously possessing tumor-targeting, real-time drug monitoring and effective treatment, will potentially enhance the performance in cancer therapy.