Icariin-loaded sulfonated polyetheretherketone with osteogenesis promotion and osteoclastogenesis inhibition properties via immunomodulation for advanced osseointegration. Issue 18 (13th April 2022)

• Record Type: Journal Article
• Authors: Chai, Haobu; Sang, Shang; Luo, Yao; He, Renke; Yuan, Xiangwei; Zhang, Xianlong
• Is Part Of: Journal of materials chemistry. Volume 10:Issue 18(2022)
• Page Start: 3531
• Page End: 3540
• Publication Date: 2022-04-13
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d1tb02802b
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Icariin-loaded sulfonated PEEK can promote osteogenic differentiation and inhibit osteoclast differentiation by regulating macrophage polarization, thereby enhancing osseointegration. Abstract : Preventing prosthesis loosening due to insufficient osseointegration is critical for patients with osteoporosis. Endowing implants with immunomodulatory function can effectively enhance osseointegration. In this work, we loaded icariin (ICA) onto 3D porous sulfonated PEEK (SPEEK) via polydopamine (PDA) modification. Modified ICA-PDA@SPEEK not only promoted the polarization of macrophages to the anti-inflammatory M2 type, but also enhanced the osteogenesis of bone mesenchymal stem cells (BMSCs) and inhibited RANKL-induced osteoclastogenesis by regulating cytokine from macrophages. In vivo experiments further showed that ICA-PDA@SPEEK regulated the host immune response and promoted osseointegration in ovariectomized (OVX) rats. The above results demonstrated that ICA-PDA@SPEEK could be an excellent orthopedic biomaterial with immunomodulatory properties.