Copper-catalyzed asymmetric alkynylation of pyrazole-4, 5-diones using chloramphenicol base-derived hydroxyl oxazoline ligands. Issue 10 (20th April 2022)

• Record Type: Journal Article
• Authors: Li, Zhao-Feng; He, Hong-Jiao; Wang, Rong-Hui; Zhou, Li-Yan; Xiao, You-Cai; Chen, Fen-Er
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 10(2022)
• Page Start: 2792
• Page End: 2796
• Publication Date: 2022-04-20
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00213b
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : The asymmetric copper-catalyzed alkynylations of pyrazole 4, 5-diones using a chloramphenicol base derived hydroxyl oxazoline ligand are reported. Diverse enantioenriched propargyl alcohols were obtained in good to excellent yields and ee's. Abstract : The asymmetric copper-catalyzed alkynylation reactions of pyrazole 4, 5-diones in the presence of a hydroxyl oxazoline ligand, which was derived from low cost, easily accessible chloramphenicol base (ANP), are reported. The notable features of this protocol include its mild and base additive free reaction conditions, and broad functional group tolerance.