Pharmacotherapy focusing on for the management of otitis media with effusion in children: Systematic review and meta-analysis. Issue 5 (October 2022)

• Record Type: Journal Article
• Authors: Ikeda, Ryoukichi; Hidaka, Hiroshi; Ito, Makoto; Kamide, Yosuke; Kuroki, Haruo; Nakano, Atsuko; Yoshida, Haruo; Takahashi, Haruo; Iino, Yukiko; Harabuchi, Yasuaki; Kobayashi, Hitome
• Is Part Of: Auris nasus larynx. Volume 49:Issue 5(2022)
• Page Start: 748
• Page End: 754
• Publication Date: 2022-10
• Subjects: Otitis media with effusion -- Steroid nasal spray -- Carbocysteine -- Antihistamines, leukotriene receptor antagonist -- Systematic review -- Meta-analysis; Otolaryngology -- Periodicals; Electronic journals; 616
• DOI: 10.1016/j.anl.2022.03.017
• Languages: English
• ISSNs: 0385-8146

Abstract

Abstract: Objective: To examine the evidence for treating children with otitis media with effusion with pharmacotherapy. Data Sources: For the systematic review, data were retrieved from PubMed, Cochrane database, and the Japan Medical Abstracts Society Database (1st January 1995 through 31th May 2019). Study Selection: Articles addressing pharmacotherapy for the management of otitis media with effusion in children were selected in English. Data Extraction: The database was searched using the keywords "Otitis Media with effusion or secretory otitis media" and the following medical agents: carbocysteine, antihistamines, leukotriene receptor antagonist, and steroid nasal spray. Data Synthesis: After a critical review of 18 studies, studies addressing steroid nasal spray were eligible for quantitative synthesis. Intranasal steroids for OME showed no benefit with OR 1.155 (95% CI 0.834-1.598) within one month. Conversely, intranasal steroids have effects for OME with OR 1.858 (95% CI 1.240-2.786) for more than one month. Conclusions: We found evidence of benefit from treatment of OME in children with intranasal steroids and S-carboxymethylcysteine at longer-term follow-up.