Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021. (21st December 2021)

• Record Type: Journal Article
• Authors: Lewis, Nathaniel M; Naioti, Eric A; Self, Wesley H; Ginde, Adit A; Douin, David J; Keipp Talbot, H; Casey, Jonathan D; Mohr, Nicholas M; Zepeski, Anne; Gaglani, Manjusha; Ghamande, Shekhar A; McNeal, Tresa A; Shapiro, Nathan I; Gibbs, Kevin W; Clark Files, D; Hager, David N; Shehu, Arber; Prekker, Matthew E; Erickson, Heidi L; Gong, Michelle N; Mohamed, Amira; Henning, Daniel J; Steingrub, Jay S; Peltan, Ithan D; Brown, Samuel M; Martin, Emily T; Hubel, Kinsley; Hough, Catherine L; Busse, Laurence W; ten Lohuis, Caitlin C; Duggal, Abhijit; Wilson, Jennifer G; Gordon, Alexandra J; Qadir, Nida; Chang, Steven Y; Mallow, Christopher; Rivas, Carolina; Babcock, Hilary M; Kwon, Jennie H; Exline, Matthew C; Halasa, Natasha; Chappell, James D; Lauring, Adam S; Grijalva, Carlos G; Rice, Todd W; Rhoads, Jillian P; Stubblefield, William B; Baughman, Adrienne; Womack, Kelsey N; Lindsell, Christopher J; Hart, Kimberly W; Zhu, Yuwei; Schrag, Stephanie J; Kobayashi, Miwako; Verani, Jennifer R; Patel, Manish M; Tenforde, Mark W;
• Is Part Of: Journal of infectious diseases. Volume 225:Number 10(2022)
• Page Start: 1694
• Page End: 1700
• Publication Date: 2021-12-21
• Subjects: chronic medical conditions -- COVID-19 -- preexisting conditions -- vaccine effectiveness; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab619
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March–August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR–negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%–98%) among patients with no chronic medical conditions and 83% (95% CI, 76%–88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18–64 years versus ≥65 years ( P > .05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.