Complicated multiple organ infection of Purpureocillium lilacinum and varicella-zoster virus infection in a patient with Evans' syndrome. Issue 2 (April 2022)

• Record Type: Journal Article
• Authors: Hu, Xiangrong; Zhang, Li; Lin, Qingsong; Zhang, Fengkui; Zhao, Xin
• Is Part Of: Blood science. Volume 4:Issue 2(2022)
• Page Start: 89
• Page End: 92
• Publication Date: 2022-04
• Subjects: Evans' syndrome -- Fungal infection -- Posaconazole -- Purpureocillium lilacinum -- Varicella-zoster virus; Hematology -- Periodicals; Blood -- Periodicals; Hematology; Blood; Hematology; Blood; Electronic journals; Periodicals; 616.15005
• DOI: 10.1097/BS9.0000000000000107
• Languages: English
• ISSNs: 2543-6368

Abstract

Abstract : Abstract: Purpureocillium lilacinum ( P lilacinum) is a rare pathogenic fungus, which mainly involves immunocompromised individuals. Here, we report a case of complicated multiple-organ infections involving skin, lungs, and spleen in a 63-year-old female with Evans' syndrome after 9 months of glucocorticoid treatment. Microbial examinations of skin biopsy and blood samples revealed P lilacinum infections. Posaconazole was effective in this patient. During anti-fungi treatment, she developed varicella-zoster virus infection and was diagnosed through next-generation sequencing examination. In conclusion, P lilacinum may affect different organ systems and is susceptible to posaconazole treatment. The molecular-based methods like microbial cell-free DNA sequencing could provide accurate and timely identification of a wide range of infections.